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Biodistribution of phenylboric acid derivative entrapped lipiodol and 4-borono-2-18F-fluoro-l-phenylalanine-fructose in GP7TB liver tumor bearing rats for BNCT
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Biodistribution of phenylboric acid derivative entrapped lipiodol and 4-borono-2-18F-fluoro-l-phenylalanine-fructose in GP7TB liver tumor bearing rats for BNCT

A.H. Liao, F.I. Chou, Y.C. Kuo, H.W. Chen, J.J. Kai, C.W. Chang, F.D. ChenJ.J. Hwang
Applied Radiation and Isotopes, 卷.68(3), 頁碼.422-426
03/2010
PMID: 20056428

摘要

Biodistribution BNCT BPA-fructose GP7TB liver tumor PBAD-lipiodol Radiation
A new phenylboric acid derivative entrapped lipiodol (PBAD-lipiodol) was developed as a boron carrier for the boron neutron capture therapy (BNCT) of hepatoma in Taiwan. The biodistribution of both PBAD-lipiodol and BPA-fructose was assayed in GP7TB hepatoma-bearing rat model. The highest uptake of PBAD-lipiodol was found at 2 h post injection. The application of BNCT for the hepatoma treatment in tumor-bearing rats is suggested to be 2-4 h post PBAD-lipiodol injection. © 2009 Elsevier Ltd. All rights reserved.

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