摘要
Sulfonamides are vital scaffolds in pharmaceuticals and materials chemistry. While most oxidative sulfonamide syntheses predominantly relied iodine-mediated protocols, bromine-based systems remain largely unexplored. In this study, we report a CBr4-mediated oxidative coupling of sodium benzenesulfinamide with diverse primary and secondary amines under metal-free conditions, offering an efficient and sustainable alternative to conventional approaches. The reaction proceeds smoothly under mild conditions, affording a broad range of sulfonamides in high yields with excellent functional group compatibility. Furthermore, comparative studies under batch, continuous-flow, and ultrasound-assisted conditions revealed that the continuous-flow process remarkably reduced reaction time from 4 h to 15.7 min while eliminating the need for external heating and maintaining superior yields. This work not only provides a practical and efficient route to sulfonamides but also fills a significant methodological gap in halogen-mediated oxidative coupling chemistry.