摘要
Soluble amyloid-β oligomers (oAβ 42 )-induced neuronal death and inflammation response has been recognized as one of the major causes of Alzheimer’s disease (AD). In this work, a novel strategy adopting silica-coated iron oxide stir bar (MSB)-based AD therapy system via magnetic stirring-induced capture of oAβ 42 into magnetic plaques (mpAβ 42 ) and activation of microglia on cellular plaque clearance was developed. With oAβ 42 being effectively converted into mpAβ 42 , the neurotoxicity toward neuronal cells was thus greatly reduced. In addition to the good preservation of neurite outgrowth through the diminished uptake of oAβ 42 , neurons treated with oAβ 42 under magnetic stirring also exhibited comparable neuron-specific protein expression to those in the absence of oAβ 42 . The phagocytic uptake of mpAβ 42 by microglia was enhanced significantly as compared to the counterpart of oAβ 42 , and the M1 polarization of microglia often occurring after the uptake of oAβ 42 restricted to an appreciable extent. As a result, the inflammation induced by pro-inflammatory cytokines was greatly alleviated.