Catalytic annulation of 1-substituted-3-en-1-yn-5-als with cycloalkanones using acid-base dual catalysts

Chia-Wei Yang; Rai-Shung Liu

doi:10.1016/j.tetlet.2007.06.045

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Catalytic annulation of 1-substituted-3-en-1-yn-5-als with cycloalkanones using acid-base dual catalysts

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Catalytic annulation of 1-substituted-3-en-1-yn-5-als with cycloalkanones using acid-base dual catalysts

Chia-Wei Yang and Rai-Shung Liu

Tetrahedron Letters, Vol.48(33), pp.5887-5889

13/08/2007

DOI: https://doi.org/10.1016/j.tetlet.2007.06.045

Abstract

CpRu(PPh ₃ ) ₂ Cl and DBU dual catalysts in combination enable a one-pot annulation of 1-R-3-en-1-yn-5-als (R = aryl, alkenyl, alkyl) and cycloalkanones to give highly substituted benzene products. This catalytic reaction consists of a tandem aldol condensation, dehydration and aromatization through a 1,7-hydrogen shift; the resulting 1-indanones and α-tetralones are obtained in moderate to good yields. © 2007 Elsevier Ltd. All rights reserved.

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Title: Catalytic annulation of 1-substituted-3-en-1-yn-5-als with cycloalkanones using acid-base dual catalysts
Creators - without role: Chia-Wei Yang - Department of Chemistry , National Tsing-Hua University
Rai-Shung Liu - Department of Chemistry , National Tsing-Hua University
Publication Details: Tetrahedron Letters, Vol.48(33), pp.5887-5889
Identifiers: 9957769832306774
Academic Unit: Department of Chemistry, College of Science, National Tsing Hua University
Language: English
Resource Type: Journal article

Catalytic annulation of 1-substituted-3-en-1-yn-5-als with cycloalkanones using acid-base dual catalysts

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