摘要
Polystyrene-imidazolium (PS-Im + Cl - ) monolith was synthesized within a flow-through microfluidic chip and Teflon tubing for activating [ 18 F]fluoride ions. The [ 18 F]fluoride ions were trapped on the PS-Im + monolith and were subsequently released with various phase-transfer catalysts (PTC) and carbonate or bicarbonate bases in microliter volumes of organic solvents containing 0.5% of water. The activated [ 18 F]fluoride complex released from the PS-Im + monolith was used to fluorinate various known PET probe precursors with diverse reactivity in a subsequent flow-through microfluidic chip without performing additional azeotropic distillation. The fluorination yields under the optimized condition for the protected [ 18 F]FDG, protected [ 18 F]FLT, 4-[ 18 F]fluoroethylbenzoate, and [ 18 F]fallypride were 93%, 96%, 77% and 73%, respectively. This method, utilizing the PS-Im + monolith on a flow through microfluidic platform, enables the entire fluorine-18 radiochemistry to be performed on a flow-through microfluidic device within a shorter synthesis time and with fluorination efficiency that is comparable to or higher than conventional means. © 2014 the Partner Organisations.