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Cell culture arrays using micron-sized ferromagnetic ring-shaped thin films
Journal article   Peer reviewed

Cell culture arrays using micron-sized ferromagnetic ring-shaped thin films

Chen-Yu Huang, Mei-Feng Lai, Tzong-Rong Ger and Zung-Hang Wei
Journal of Applied Physics, Vol.117(17), 17B309
07/05/2015

Abstract

Cell patterning has become an important technology for tissue engineering. In this research, domain walls are formed at the two ends of a ferromagnetic ring thin film after applying a strong external magnetic field, which can effectively attract magnetically labeled cells and control the position for biological cell. Magnetophoresis experiment was conducted to quantify the magnetic nanoparticle inside the cells. A ring-shaped magnetic thin films array was fabricated through photolithography. It is observed that magnetically labeled cells can be successfully attracted to the two ends of the ring-shaped magnetic thin film structure and more cells were attracted and further attached to the structures. The cells are co-cultured with the structure and kept proliferating; therefore, such ring thin film can be an important candidate for in-vitro biomedical chips or tissue engineering.

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