Abstract
A high-frequency magnetic field (HFMF) triggered pulsatile drug delivery ferrogel with a mechanically reliable and flexible hybrid structure composed of gelatin and magnetic nanoparticles (nanomagnets) were studied. A highly controllable and repeatable burst release with desirable precision from the ferrogels under cyclic exposures to the high-frequency magnetic stimuli were also analyzed. The nanomagnets were essentially chemically bounded with the gelatin matrix to form the ferrogel, which further evidenced from XPS analysis. The higher binding energy was believed to be a result of esterification between hydroxide moiety on the surface of the MNPs and carboxylic acid group of gelatin, indicating an excellent chemical affinity between both participating phases and a strong solid network of the ferrogels. One clinically important advantage of this high-frequency-modulated fast-acting drug delivery ferrogel is that it can potentially meet immediate urgent physiological needs.