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Counterattack reagents:hexamethyldisilane and 1,2-dimethyl-1,1,2,2-tetraphenyldisilane in the synthesis of polysilylated hydrazines
Journal article   Peer reviewed

Counterattack reagents:hexamethyldisilane and 1,2-dimethyl-1,1,2,2-tetraphenyldisilane in the synthesis of polysilylated hydrazines

Jih Ru Hwu and Naelong Wang
Tetrahedron, Vol.44(13), pp.4181-4196
1988

Abstract

Biochemistry Drug Discovery Organic Chemistry
Polysilylated hydrazines have wide applicability. It is tedious to prepare these compounds by classic means. However, using hexamethyldisilane and 1,2-dimethyl-1,1,2,2-tetraphenyldisilane as counterattack reagents, we synthesized polysilylated hydrazines under alkaline conditions in good to excellent yields. This one-pot method is expedient and more efficient than other procedures. Polysilylated hydrazines were found to react with aldehydes or ketones in the presence of a catalytic amount of trimethylsilyl trifluoromethanesulfonate to give the corresponding hydrazones under anhydrous conditions. © 1988.

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