Abstract
Taxol-containing aminophosphates 5-7 were synthesized as protaxols by a 'one-flask' method; the intrinsic zwitterionic character increases their solubility to about six times higher than that of taxol in a phosphate buffer solution.
- Title
- Design and synthesis of new taxol-containing aminophosphates as protaxols
- Creators - without role
- Jih Ru Hwu - Institute of Chemistry, Academia SinicaGholam H. Hakimelahi - Institute of Chemistry, Academia SinicaThota Sambaiah - National Tsing Hua UniversityHimatkumar V. Patel - National Tsing Hua UniversityShwu-Chen Tsay - National Tsing Hua UniversityYiu-Kay Lai - Organosilicon and Synthesis Lab. , Department of Chemistry , National Tsing Hua UniversityChien-Hui Lieu - National Tsing Hua University
- Publication Details
- Bioorganic and Medicinal Chemistry Letters, Vol.7(5), pp.545-548
- Identifiers
- 9957770612306774
- Academic Unit
- National Tsing Hua University
- Language
- English
- Resource Type
- Journal article