Design and synthesis of paclitaxel-containing aminoester phosphate and phosphoamidate

Jih Ru Hwu; Shwu-Chen Tsay; Thota Sambaiah; Yiu-Kay Lai; Chien-Hui Lieu; Gholam H. Hakimelahi; Ke-Yung King

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Design and synthesis of paclitaxel-containing aminoester phosphate and phosphoamidate

Journal article

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Design and synthesis of paclitaxel-containing aminoester phosphate and phosphoamidate

Jih Ru Hwu, Shwu-Chen Tsay, Thota Sambaiah, Yiu-Kay Lai, Chien-Hui Lieu, Gholam H. Hakimelahi and Ke-Yung King

Mendeleev Communications, Vol.11(6), pp.216-217

2001

Abstract

Paclitaxel-containing aminoester phosphate 4 and phosphoamidate 9 were synthesised and found to possess anticancer activity against HL-60 leukemia cells; their solubility in a phosphate buffer solution was about 16 times higher than that of paclitaxel.

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Title: Design and synthesis of paclitaxel-containing aminoester phosphate and phosphoamidate
Creators - without role: Jih Ru Hwu - Organosilicon and Synthesis Lab. , Department of Chemistry , National Tsing Hua University
Shwu-Chen Tsay - National Tsing Hua University
Thota Sambaiah - National Tsing Hua University
Yiu-Kay Lai - Organosilicon and Synthesis Lab. , Department of Chemistry , National Tsing Hua University
Chien-Hui Lieu - National Tsing Hua University
Gholam H. Hakimelahi - National Tsing Hua University
Ke-Yung King - National Tsing Hua University
Identifiers: 9957772610506774
Academic Unit: National Tsing Hua University
Language: English
Resource Type: Journal article
Publication Details: Mendeleev Communications, Vol.11(6), pp.216-217

Design and synthesis of paclitaxel-containing aminoester phosphate and phosphoamidate

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