Design of multivalent galactosyl carborane as a targeting specific agent for potential application to boron neutron capture therapy

Chian-Hui Lai; Yu-Chuan Lin; Fong-In Chou; Chien-Fu Liang; En-Wei Lin; Yung-Jen Chuang; Chun-Cheng Lin

doi:10.1039/c1cc14447b

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Design of multivalent galactosyl carborane as a targeting specific agent for potential application to boron neutron capture therapy

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Design of multivalent galactosyl carborane as a targeting specific agent for potential application to boron neutron capture therapy

Chian-Hui Lai, Yu-Chuan Lin, Fong-In Chou, Chien-Fu Liang, En-Wei Lin, Yung-Jen Chuang and Chun-Cheng Lin

Chemical Communications, Vol.48(4), pp.612-614

14/01/2012

DOI: https://doi.org/10.1039/c1cc14447b

Abstract

A multivalent galactosyl carborane derivative 10 (dendritic glyco-borane, DGB) was synthesized and demonstrated as a potential cell-targeting agent in BNCT with HepG2 cells. DGB 10 improved the delivery of boron to HepG2 cells and neutron irradiation data show DGB 10 with ten-fold improvement at killing the HepG2 cells over BSH. © 2012 The Royal Society of Chemistry.

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Title: Design of multivalent galactosyl carborane as a targeting specific agent for potential application to boron neutron capture therapy
Creators - without role: Chian-Hui Lai - Department of Chemistry , National Tsing Hua University
Yu-Chuan Lin - National Tsing Hua University
Fong-In Chou - Department of Chemistry , National Tsing Hua University
Chien-Fu Liang - Department of Chemistry , National Tsing Hua University
En-Wei Lin - Department of Chemistry , National Tsing Hua University
Yung-Jen Chuang - Department of Chemistry , National Tsing Hua University
Chun-Cheng Lin - Department of Chemistry , National Tsing Hua University
Publication Details: Chemical Communications, Vol.48(4), pp.612-614
Identifiers: 9957766574306774
Academic Unit: Department of Medical Science, College of Life Science and Medicine, National Tsing Hua University
Language: English
Resource Type: Journal article

Design of multivalent galactosyl carborane as a targeting specific agent for potential application to boron neutron capture therapy

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