Detection of DNA Hybridization Beyond the Debye Screening Length by CMOS Capacitive Sensors

Chang-Hung Lin; Yuan-Chieh Lee; Chia-Ming Yang; Michael S.-C. Lu

doi:10.1109/LED.2022.3182784

Detection of DNA Hybridization Beyond the Debye Screening Length by CMOS Capacitive Sensors

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Detection of DNA Hybridization Beyond the Debye Screening Length by CMOS Capacitive Sensors

Chang-Hung Lin, Yuan-Chieh Lee, Chia-Ming Yang 和 Michael S.-C. Lu

IEEE Electron Device Letters

2022

DOI: https://doi.org/10.1109/LED.2022.3182784

摘要

Biosensors

Capacitance

Capacitive sensors

CMOS

Debye length

DNA

Electrodes

Frequency modulation

Interdigitated electrodes

Sensors

Electronic

Optical and Magnetic Materials

Electrical and Electronic Engineering

Capacitive sensors are very promising to provide label-free and real-time biological detection for point-of-care diagnostic applications. However, the Debye charge screening effect severely hinders the detection under high ionic strength condition, such as in human serum. Therefore, most measurements are made indirectly in diluted solutions. To solve this problem, electric field modulation between the interdigitated sensing electrodes is applied in this study to increase the Debye length. For DNA (deoxyribonucleic acid) measurements, the two designs operating around 90 and 40 MHz exhibited sensitivities of 2.6 fF/log[DNA] and 10.8 fF/log[DNA] up to 100 fM and a response time of 12 minutes.

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題名: Detection of DNA Hybridization Beyond the Debye Screening Length by CMOS Capacitive Sensors
翻譯題名: Detection of DNA Hybridization Beyond the Debye Screening Length by CMOS Capacitive Sensors
創作者：: Chang-Hung Lin (作者) - National Tsing Hua University
Yuan-Chieh Lee (作者) - Department of Electrical Engineering and the Institute of Electronics Engineering, National Tsing Hua University, Hsinchu, Taiwan
Chia-Ming Yang (作者) - Department of Electrical Engineering and the Institute of Electronics Engineering, National Tsing Hua University, Hsinchu, Taiwan
Michael S.-C. Lu (作者) - National Tsing Hua University
著作權: IEEE
學術資源類型: 期刊文章
出版日期: 2022
出版資訊: IEEE Electron Device Letters
語言: 英語

Detection of DNA Hybridization Beyond the Debye Screening Length by CMOS Capacitive Sensors

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