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Determining the Zero-Force Binding Energetics of Intercalated DNA Complex Using Single Molecule Approach
期刊文章

Determining the Zero-Force Binding Energetics of Intercalated DNA Complex Using Single Molecule Approach

Tzu-Sen Yang, Yujia Cui, Chien-Ming Wu, Jem-Mau Lo, Chi-Shiun Chiang, Wun-Yi Shu, Wei-Ju Chung, Chung-Shan Yu, Kuo-Ning Chiang 和 Ian C. Hsu
ChemPhysChem ChemPhysChem, 卷.10(16), 頁碼.2791-2794
2009
DOI: https://doi.org/10.1002/cphc.200900435

摘要

DNA;drug design;optical tweezers;radiation therapy;single-molecule studies
Binding behavior of DNA: A wormlike chain model is applied to determine the zero-force binding energetics of an intercalated DNA complex. A mono-intercalating agent is synthesized which can be very easily inserted into the DNA bases (see figure). This approach is particularly important in nuclear medicine and new radiation therapies.

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