Determining the zero-force binding energetics of an intercalated DNA complex by a single-molecule approach

Tzu-Sen Yang; Yujia Cui; Chien-Ming Wu; Jem-Mau Lo; Chi-Shiun Chiang; Wun-Yi Shu; Wei-Ju Chung; Chung-Shan Yu; Kuo-Ning Chiang; Lan C. Hsu

doi:10.1002/cphc.200900435

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Determining the zero-force binding energetics of an intercalated DNA complex by a single-molecule approach

Journal article

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Determining the zero-force binding energetics of an intercalated DNA complex by a single-molecule approach

Tzu-Sen Yang, Yujia Cui, Chien-Ming Wu, Jem-Mau Lo, Chi-Shiun Chiang, Wun-Yi Shu, Wei-Ju Chung, Chung-Shan Yu, Kuo-Ning Chiang and Lan C. Hsu

ChemPhysChem, Vol.10(16), pp.2791-2794

09/11/2009

DOI: https://doi.org/10.1002/cphc.200900435

Abstract

DNA

Drug design

Optical tweezers

Radiation therapy

Single-molecule studies

Binding behavior of DNA: A wormlike chain model is applied to determine the zero-force binding energetics of an intercalated DNA complex. A mono-intercalating agent is synthesized which can be very easily inserted into the DNA bases (see figure). This approach is particularly important in nuclear medicine and new radiation therapies. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

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Title: Determining the zero-force binding energetics of an intercalated DNA complex by a single-molecule approach
Creators - without role: Tzu-Sen Yang - Taipei Medical University
Yujia Cui - National Tsing Hua University
Chien-Ming Wu - Department of Biomedical Engineering and Environmental Sciences , National Tsing Hua University
Jem-Mau Lo - Department of Biomedical Engineering and Environmental Sciences , National Tsing Hua University
Chi-Shiun Chiang - Department of Biomedical Engineering and Environmental Sciences , National Tsing Hua University
Wun-Yi Shu - Department of Biomedical Engineering and Environmental Sciences , National Tsing Hua University
Wei-Ju Chung - Department of Biomedical Engineering and Environmental Sciences , National Tsing Hua University
Chung-Shan Yu - Department of Biomedical Engineering and Environmental Sciences , National Tsing Hua University
Kuo-Ning Chiang - Department of Biomedical Engineering and Environmental Sciences , National Tsing Hua University
Lan C. Hsu - Department of Biomedical Engineering and Environmental Sciences , National Tsing Hua University
Identifiers: 9957775015306774
Academic Unit: Institute of Nuclear Engineering and Science, College of Nuclear Science, National Tsing Hua University; Department of Power Mechanical Engineering, College of Engineering, National Tsing Hua University; National Tsing Hua University
Language: English
Resource Type: Journal article
Publication Details: ChemPhysChem, Vol.10(16), pp.2791-2794

Determining the zero-force binding energetics of an intercalated DNA complex by a single-molecule approach

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