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Development of a povarov reaction/carbene generation sequence for alkenyldiazocarbonyl compounds
Journal article   Peer reviewed

Development of a povarov reaction/carbene generation sequence for alkenyldiazocarbonyl compounds

Appaso Mahadev Jadhav, Vinayak Vishnu Pagar and Rai-Shung Liu
Angewandte Chemie - International Edition, Vol.51(47), pp.11809-11813
19/11/2012

Abstract

carbenes cycloaddition diazo compounds heterocycles synthetic methods
Rings aplenty: A HOTf-catalyzed (Tf=trifluoromethanesulfonyl) Povarov reaction of alkenyldiazo species has been developed and delivers diazo-containing cycloadducts stereoselectively (see scheme). The resulting cycloadducts provide access to six- and seven-membered azacycles through the generation of metal carbenes as well as the functionalization of diazo group. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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