Abstract
A diverse array of oxometallic species were examined as catalysts for a test direct condensation of benzoic acid and 2-phenylethanol in 1:1 stoichiometry. Besides group IVB MOCl 2 -XH 2 O and TiOX 2 -xH 2 O, group VB VOCl 2 -xTHF and group IVB TiO(acac) 2 were found to be the most efficient and water-tolerant catalysts for the test reaction. The new neutral catalytic protocol with the optimal TiO(acac) 2 tolerates many stereo/electronic structural variations in both (di)-acid (1°-3° alkyl and aryl) and (di)alcohol (1°, 2° alkyl, and aryl) components with high chemoselectivity. © 2005 American Chemical Society.