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Effects of neighboring glycans on antibody-carbohydrate interaction
Journal article   Peer reviewed

Effects of neighboring glycans on antibody-carbohydrate interaction

Chi-Hui Liang, Sheng-Kai Wang, Chin-Wei Lin, Cheng-Chi Wang, Chi-Huey Wong and Chung-Yi Wu
Angewandte Chemie - International Edition, Vol.50(7), pp.1608-1612
11/02/2011

Abstract

carbohydrates conjugation glycans microarray vaccine design
Who can? Glycan! Heterogeneous glycan microarrays were prepared for the study of antibody binding specificity and affinity. It was found that heterogeneous glycans provide better binding affinity compared to their individual components (see picture), thereby suggesting a new strategy for carbohydrate-based vaccine design. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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