摘要
We have established a visible-light-driven oxidative catalytic system to form hydroxyl-functionalized aryl ketones and propargyl amines using cuboctahedral Cu2O particles as a recyclable photocatalyst in the presence of oxygen at room temperature. Here, the in situ-generated cuprous oxide particle-phenylacetylide complex serves as a key light-absorbing photocatalyst (lambda(max) = 465 nm). This simple reaction setup can be readily scaled up, achieving high yields and providing significant value to the pharmaceutical industry for synthesizing molecular drugs such as Pitofenone, Fenofibrate, Ciproxifan, and Pargyline. In addition, the green chemistry metrics and Eco Scale evaluations prove that the current protocol is a simple, mild, and acceptable green organic synthesis process. This work highlights the potential of Cu2O cubooctahedrons as effective recyclable photocatalysts for organic transformations, reduces the generation of reaction wastes, and offers a promising approach for eco-friendly industrial applications.