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Environment-sensitive fluorescent turn-on probes targeting hydrophobic ligand-binding domains for selective protein detection
Journal article   Peer reviewed

Environment-sensitive fluorescent turn-on probes targeting hydrophobic ligand-binding domains for selective protein detection

Yu-De Zhuang, Po-Yi Chiang, Chia-Wen Wang and Kui-Thong Tan
Angewandte Chemie - International Edition, Vol.52(31), pp.8124-8128
29/07/2013
DOI: https://doi.org/10.1002/anie.201302884

Abstract

environment-sensitive fluorophores fluorescent probes non-enzymatic proteins protein detection protein modifications
Bind and shine: An approach for the selective detection of both enzymes and non-enzymatic proteins using an environment-sensitive fluorescent turn-on probe is described (see scheme). This approach targets the hydrophobic ligand-binding domain of the target protein to trigger the fluorescence turn-on and was shown to be specific for the targeted protein. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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