Enzymatic radiofluorination: Fluorinase accepts methylaza-analog of SAM as substrate for FDA synthesis

Maxim E. Sergeev; Federica Morgia; Muhammad R. Javed; Mami Doi; Pei Y. Keng

doi:10.1016/j.molcatb.2013.07.015

Enzymatic radiofluorination: Fluorinase accepts methylaza-analog of SAM as substrate for FDA synthesis

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Enzymatic radiofluorination: Fluorinase accepts methylaza-analog of SAM as substrate for FDA synthesis

Maxim E. Sergeev, Federica Morgia, Muhammad R. Javed, Mami Doi 和 Pei Y. Keng

Journal of Molecular Catalysis B: Enzymatic, 卷.97, 頁碼.74-79

2013

DOI: https://doi.org/10.1016/j.molcatb.2013.07.015

摘要

Enzymatic catalysis

Fluorinase

Nucleophilic fluorination

Substrate specificity

Catalysis

Bioengineering

Biochemistry

Process Chemistry and Technology

Methylaza-analog of S-adenosyl-l-methionine (MeAzaAdoMet) was found to be a substrate for fluorinase. This is the first discovery of a new substrate for fluorinase that can be accessed synthetically in high purity. The activity of fluorinase for the new MeAzaAdoMet and [ ¹⁸ F]fluoride ion was 32% in 180 min. © 2013 Elsevier B.V. All rights reserved.

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題名: Enzymatic radiofluorination: Fluorinase accepts methylaza-analog of SAM as substrate for FDA synthesis
翻譯題名: Enzymatic radiofluorination: Fluorinase accepts methylaza-analog of SAM as substrate for FDA synthesis
創作者：: Maxim E. Sergeev (作者) - University of California, Los Angeles
Federica Morgia (作者) - University of California, Los Angeles
Muhammad R. Javed (作者) - University of California, Los Angeles
Mami Doi (作者) - Waseda University
Pei Y. Keng (作者) - University of California, Los Angeles
學術資源類型: 期刊文章
出版日期: 2013
出版資訊: Journal of Molecular Catalysis B: Enzymatic, 卷.97, 頁碼.74-79
語言: 英語

Enzymatic radiofluorination: Fluorinase accepts methylaza-analog of SAM as substrate for FDA synthesis

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