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Enzymatic sculpting of nanoscale and microscale surface topographies
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Enzymatic sculpting of nanoscale and microscale surface topographies

Jen-Huang Huang, Arul JayaramanVictor M. Ugaz
Angewandte Chemie - International Edition, 卷.51(38), 頁碼.9619-9623
09/2012
PMID: 22926958

摘要

biomaterials enzymes microfluidics nanofabrication patterning Catalysis Chemistry (all)
Lithography-free etching of complex surface features is achieved by harnessing the enzyme proteinase K (PK), controlled by bovine serum albumin (BSA), to digest a biodegradable polymer. This bio-sculpting process is used to construct a membraneless filtration device for the size-based isolation and enrichment of cells from whole blood. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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