Feasibility of Using High-Contrast Grating as a Point-of-Care Sensor for Therapeutic Drug Monitoring of Immunosuppressants

Y.-C. Liu; C. Thantrakul; S. Kan; C. Chang-Hasnain; D.-R. Ho

doi:10.1109/JTEHM.2020.2966478

期刊文章

Feasibility of Using High-Contrast Grating as a Point-of-Care Sensor for Therapeutic Drug Monitoring of Immunosuppressants

Y.-C. Liu, C. Thantrakul, S. Kan, C. Chang-Hasnain 和 D.-R. Ho

IEEE Journal of Translational Engineering in Health and Medicine, 卷.8

2020

DOI: https://doi.org/10.1109/JTEHM.2020.2966478

Web of Science ID: WOS:000528029200001

摘要

metamaterials

Point-of-care

therapeutic drug monitoring

transplantation

Drug products

Efficiency

Grafts

Metamaterials

Patient monitoring

Personalized medicine

Transplantation (surgical)

cyclosporine

Detection efficiency

Graft functions

High contrast grating (HCG)

High-contrast gratings

Immunosuppressants

Organ transplants

Point of care

Therapeutic drug monitoring

Article

controlled study

drug monitoring

feasibility study

in vitro study

point of care testing

prescription

Diffraction gratings

Point-of-care (POC) testing has demonstrated great transformative potential in personalized medicine. In particular, patients undergoing transplantation require POC testing to ensure appropriate serum immunosuppressant levels so as to maintain adequate graft function and survival. However, no suitable POC device for monitoring immunosuppressant levels is currently available. Exploiting the latest advances in metamaterials can lead to a breakthrough in POC testing. A high-contrast grating (HCG) biosensor is a low-cost, compact, simple-to-fabricate, and easy-to-operate structure. It is highly sensitive and robust in surface-based biomarker detection, which is favorable for the efficiency of a POC device. In this study, the feasibility of using an HCG as a POC sensor for therapeutic drug monitoring of immunosuppressants was evaluated. The detection efficiency of the most commonly prescribed immunosuppressive medication cyclosporine A by using this sensor was demonstrated to be comparable to those of conventional commercial kits, suggesting that the sensor has the potential to be used as a rapid detection and feedback platform for increasing drug compliance and improving new organ transplant survival. © 2013 IEEE.

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題名: Feasibility of Using High-Contrast Grating as a Point-of-Care Sensor for Therapeutic Drug Monitoring of Immunosuppressants
創作者：: Y.-C. Liu - University of California, Berkeley
C. Thantrakul - University of California, Berkeley
S. Kan - University of California, Berkeley
C. Chang-Hasnain - University of California, Berkeley
D.-R. Ho - Chang Gung University of Science and Technology
出版者: Institute of Electrical and Electronics Engineers Inc.; PISCATAWAY
總頁數: 6
補助款備註: National Applied Research Laboratories of Taiwan through Berkeley-Taiwan Biomedical Fellowship Program Chang Gung Memorial Hospital: CMRPG6F0262, CMRPG6C0313 Stanford-Taiwan Biomedical Fellowship Program
This work was supported in part by the National Applied Research Laboratories of Taiwan through Berkeley-Taiwan Biomedical Fellowship Program, in part by the Stanford-Taiwan Biomedical Fellowship Program, and in part by the Chang Gung Memorial Hospital under Grant CMRPG6F0262 and Grant CMRPG6C0313.
學術資源類型: 期刊文章
出版日期: 2020
出版資訊: IEEE Journal of Translational Engineering in Health and Medicine, 卷.8
語言: 英語

Feasibility of Using High-Contrast Grating as a Point-of-Care Sensor for Therapeutic Drug Monitoring of Immunosuppressants

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