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Formal synthesis of 3-deoxy-d-manno-octulosonic acid (KDO) and 3-deoxy-d-arabino-2-heptulosonic acid (DAH)
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Formal synthesis of 3-deoxy-d-manno-octulosonic acid (KDO) and 3-deoxy-d-arabino-2-heptulosonic acid (DAH)

Tapankumar Pradhan, Chuncheng LinKwokkong Tony Mong
Synlett, 卷.24(2), 頁碼.219-222
2013

摘要

carbohydrates Corey-Fuchs cyclization Wittig Organic Chemistry
Practical synthetic routes to 3-deoxy-d-manno-octulosonic acid (KDO) and 3-deoxy-d-arabino-2-heptulosonic acid (DAH) from common sugar substrates are reported. Chain homologation of the sugar substrates was accomplished by Wittig olefination and Corey-Fuchs alkynylation. A new cyclization strategy was investigated to access the desired pyranosyl isomer of the KDO target. © Georg Thieme Verlag Stuttgart New York.

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