Glycosylated nordihydroguaiaretic acids as anti-cancer agents

Jih Ru Hwu; Chuan-I Hsu; Ming-Hua Hsu; Yu-Chuan Liang; Ru Chih C. Huang; Yuan C. Lee

doi:10.1016/j.bmcl.2010.10.137

Back

Journal article

Glycosylated nordihydroguaiaretic acids as anti-cancer agents

Jih Ru Hwu, Chuan-I Hsu, Ming-Hua Hsu, Yu-Chuan Liang, Ru Chih C. Huang and Yuan C. Lee

Bioorganic and Medicinal Chemistry Letters, Vol.21(1), pp.380-382

01/01/2011

DOI: https://doi.org/10.1016/j.bmcl.2010.10.137

Appears in keyword about Chemistry

Abstract

Hepatocellular carcinoma

NDGA

Nordihydroguaiaretic acid

Triazol-galactose

Triazol-glucose

Three perglycosylated nordihydroguaiaretic acids (NDGA) were synthesized through the Huiseng 1,3-dipolar cycloaddition reaction. These sugar-NDGA conjugates containing triazole-linkages possessed good solubility in water. NDGA-(triazol-galactose) ₄ (12b) and NDGA-(triazol-glucose) ₄ (12c) were found to act as inhibitors against human hepatocellular carcinoma Hep3B cells in culture. © 2010 Elsevier Ltd. All rights reserved.

Metrics

1 Record Views

See more details

Details

Title: Glycosylated nordihydroguaiaretic acids as anti-cancer agents
Creators - without role: Jih Ru Hwu - National Tsing Hua University
Chuan-I Hsu - Johns Hopkins University
Ming-Hua Hsu - Department of Chemistry , National Tsing Hua University
Yu-Chuan Liang - Agricultural Biotechnology Research Center, Academia Sinica
Ru Chih C. Huang - Johns Hopkins University
Yuan C. Lee - Johns Hopkins University
Publication Details: Bioorganic and Medicinal Chemistry Letters, Vol.21(1), pp.380-382
Identifiers: 9957771841106774
Academic Unit: Institute of Molecular and Cellular Biology, College of Life Science and Medicine, National Tsing Hua University; National Tsing Hua University
Language: English
Resource Type: Journal article

Glycosylated nordihydroguaiaretic acids as anti-cancer agents

Abstract

Related links

Metrics

Details

National Tsing Hua University Social media