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Gold-Catalyzed Aminoaromatizations of 1,2-Bis(alkynyl)benzenes with Anthranils to Yield 1-Amino-2-napthaldehyde Products
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Gold-Catalyzed Aminoaromatizations of 1,2-Bis(alkynyl)benzenes with Anthranils to Yield 1-Amino-2-napthaldehyde Products

Yashwant Bhaskar PanditRai-Shung Liu
Advanced Synthesis and Catalysis
2020

摘要

1, n diynes 1,2-bis(alkynyl)benzenes amino-napthaldehyde derivatives Aminoaromatizations anthranils α-imino gold carbenes Catalysis Organic Chemistry
Gold-catalyzed aminoaromatizations of 1,n-diynes with anthranils afforded 1-amino-2-napthaldehyde derivatives efficiently. In this reaction sequence, anthranils preferably attack at gold-coordinated prop-3-yn-1-ols to generate α-imino gold carbenes that enable subsequent cyclizations with the other alkynes. Chemical functionalizations of the resulting 1-amino-2-napthaldehydes are presented to manifest the synthetic utility of these reactions. (Figure presented.).

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