摘要
One-pot synthesis of 5,6-dihydroindolo[2,1-A]isoquinolines from gold-catalyzed annulations between N-(o-Alkynylphenyl)imines and α-diazo esters is described. This cascade reaction involves an initial attack of the diazo ester at the imine to form cis-Aziridine, followed by stereoselective [3 + 3]-Annulations with the tethered arylalkyne. We have employed this new catalysis to prepare one bioactive 5,6-dihydroindolo[2,1-A]isoquinoline molecule.