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Gold-Catalyzed Oxidative Cross-Coupling Reactions among Two Distinct Arenes and One Gold Carbene with Phosphoric Acids as Cocatalysts
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Gold-Catalyzed Oxidative Cross-Coupling Reactions among Two Distinct Arenes and One Gold Carbene with Phosphoric Acids as Cocatalysts

Manoj D. Patil, Balaji S. KaleRai-Shung Liu
Advanced Synthesis and Catalysis
2020

摘要

anilines. gold carbenes gold catalysis indoles oxidative cross coupling α-aryl diazo compounds Catalysis Organic Chemistry
Gold-catalyzed oxidative cross-coupling reactions of two distinct arenes with one gold carbene furnish triarylmethane products. Notably, competitive homo-coupling reactions are efficiently suppressed with a phosphoric acid as co-catalyst (10 mol%) in THF. These cross-coupling reactions have a wide scope of applicable substrates, with respect to indoles, arylamines, and α-aryl diazo cyanides or esters. Our mechanistic analysis indicates that the basicity of the arylanilines greatly affects the cross-coupling efficiency. (Figure presented.).

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