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Gold-Catalyzed Reactions between 2‑Alkenyl-1-arylalkynes and Nitrones via 1,2-C,N-Difunctionalizations Together with the CC Double Bond Cleavage
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Gold-Catalyzed Reactions between 2‑Alkenyl-1-arylalkynes and Nitrones via 1,2-C,N-Difunctionalizations Together with the CC Double Bond Cleavage

Vikas Ashokrao Sadaphal, Hsin-Ru Wu 和 Rai-Shung Liu
Journal of organic chemistry, 卷.90(51), 頁碼.18314-18324
26/12/2025
PMID: 41383123
Web of Science ID: WOS:001638350400001

摘要

This work reports gold-catalyzed novel 1,2-C,N-difunctionalizations of 2-alkenyl-1-arylalkynes with nitrones, along with the CC double bond cleavage of substrates. Our mechanistic analysis suggests that gold directs an initial attack of N-hydroxyaniline on such enynes, followed by a cascade reaction with one nitrone molecule before the CC double bond cleavage.

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https://doi.org/10.1021/acs.joc.5c02769檢視
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