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Gold-Catalyzed Synthesis of Diaza-hexatrienes Via Diazo Attack at Vinylgold Carbenes: An Easy Access to 1 H-Pyrazolo[4,3- b]pyridine-5-ones
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Gold-Catalyzed Synthesis of Diaza-hexatrienes Via Diazo Attack at Vinylgold Carbenes: An Easy Access to 1 H-Pyrazolo[4,3- b]pyridine-5-ones

Vikas Ashokrao SadaphalRai-Shung Liu
Organic Letters
2021

摘要

Biochemistry Physical and Theoretical Chemistry Organic Chemistry
This work reports a gold-catalyzed stereoselective synthesis of highly substituted E-configured 2,3-diaza-1,3,5-hexatrienes using α-diazo nitriles and cyclopropene derivatives; such products arise from an atypical diazo attack of α-aryldiazo nitriles at vinylgold carbenes. For these 2,3-diaza-1,3,5-hexatrienes, we develop a novel anionic cyclization of derivatives of one family to form 1H-pyrazolo[4,3-b]pyridine-5-ones.

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