Abstract
We report stereoselective synthesis of bicyclo[3.2.1]oct-6-en-2-ones through Au(I)-catalyzed cycloisomerization of an allenene-acetal functionality. This cyclization is mechanistically significant because it involves an unprecedented 1,3-addition of a sp 3 -hybridized C-H bond to vinylcarbenoid moiety. Copyright © 2008 American Chemical Society.