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Gold-catalyzed intramolecular [3+2] cycloadditions of 1-Aryl-1-allene-6- enes
Journal article   Peer reviewed

Gold-catalyzed intramolecular [3+2] cycloadditions of 1-Aryl-1-allene-6- enes

Rupsha Chaudhuri, Hsin-Yi Liao and Rai-Shung Liu
Chemistry - A European Journal, Vol.15(35), pp.8895-8901
07/09/2009

Abstract

Allenes Cycloaddition Gold Heterogeneous catalysis
Treatment of 1-aryl-1-allen-6-enes with [PPh 3 AuCl]/AgSbF 6 (5 mol%) in CH 2 Cl 2 at 25°C led to intramolecular [3+2] cycloadditions, giving cis-fused dihydrobenzo[a]fluorene products efficiently and selectively. The reactions proceeded with initial formation of trans/cis mixtures of 2-alkyl-1-isopropy1-2-phenyl-1,2- dihydronaphthalene cations B, which were convertible into the desired cis-fused cycloadducts through the combined action of a gold catalyst and a Brønsted acid. Theoretic calculation supports the participation of the trans-B cation as reaction intermediate. Although HOTf showed similar activity towards several 1-aryl-1-allen-6-enes, it lacks generality for this cycloaddition reaction. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

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