Gold-catalyzed synthesis of 1,3-disubstituted benzenes through tandem allylation/cyclization reaction of alkynals

Sabyasachi Bhunia; Shariar Md. Abu Sohel; Chao-Chin Yang; Shie-Fu Lush; Fwu-Ming Shen; Rai-Shung Liu

doi:10.1016/j.jorganchem.2008.10.049

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Gold-catalyzed synthesis of 1,3-disubstituted benzenes through tandem allylation/cyclization reaction of alkynals

Sabyasachi Bhunia, Shariar Md. Abu Sohel, Chao-Chin Yang, Shie-Fu Lush, Fwu-Ming Shen and Rai-Shung Liu

Journal of Organometallic Chemistry, Vol.694(4), pp.566-570

15/02/2009

DOI: https://doi.org/10.1016/j.jorganchem.2008.10.049

Appears in keyword about Chemistry

Abstract

Alkynal

Allylation

Benzenes

Catalysis

Tandem reaction

Treatment of alkynals with 2-substituted allylsilanes and PPh ₃ AuCl/AgOTf (5/3 mol%) catalyst led to formation of 1,3-disubstituted benzenes efficiently. This reaction sequence comprises an initial allylation of aldehyde, followed by cycloisomerization of enynes; PPh ₃ AuOTf is active in both steps. © 2008 Elsevier B.V. All rights reserved.

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Title: Gold-catalyzed synthesis of 1,3-disubstituted benzenes through tandem allylation/cyclization reaction of alkynals
Creators - without role: Sabyasachi Bhunia - National Tsing Hua University
Shariar Md. Abu Sohel - National Tsing Hua University
Chao-Chin Yang - Department of Chemistry , National Tsing-Hua University
Shie-Fu Lush - Department of Biotechnology , Yuan-Pei University
Fwu-Ming Shen - Department of Biotechnology , Yuan-Pei University
Rai-Shung Liu - Department of Chemistry , National Tsing-Hua University
Identifiers: 9957774490106774
Academic Unit: Department of Chemistry, College of Science, National Tsing Hua University
Language: English
Resource Type: Journal article
Publication Details: Journal of Organometallic Chemistry, Vol.694(4), pp.566-570

Gold-catalyzed synthesis of 1,3-disubstituted benzenes through tandem allylation/cyclization reaction of alkynals

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