Logo image
Gold(I)-Catalyzed Reaction of 1-(1-Alkynyl)-cyclopropyl Ketones with Vinyldiazo Ketones for Divergent Synthesis of Substituted Furanyl Heterocycles
期刊文章   同儕審查

Gold(I)-Catalyzed Reaction of 1-(1-Alkynyl)-cyclopropyl Ketones with Vinyldiazo Ketones for Divergent Synthesis of Substituted Furanyl Heterocycles

Akshay Subhash NarodeRai-Shung Liu
Asian Journal of Organic Chemistry
2023

摘要

5-endo dig cyclization Au(I) catalysis Furan derivative pyrazole derivative thermal cyclization Organic Chemistry
Gold(I)-catalyzed reactions between 1-(1-alkynyl) cyclopropyl ketones and vinyldiazo ketones to produce substituted [(furan-3-yl)ethyl]-1H-pyrazol-5-yl)methanones are described. In this reaction sequence, we postulate vinyldiazo ketones to undergo a thermal cyclization to produce pyrazole intermediates that attack gold-containing all-carbon 1,4-carbon dipoles to afford the observed products. An atypical N(1)-regioselectivity is also rationalized in this reaction model.

相關連結

指標

1 檢視次數

詳細資料

Logo image