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Hall effect biosensors with ultraclean graphene film for improved sensitivity of label-free DNA detection
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Hall effect biosensors with ultraclean graphene film for improved sensitivity of label-free DNA detection

Phan Thi Kim Loan, Dongqin Wu, Chen Ye, Xiaoqing Li, Vu Thanh Tra, Qiuping Wei, Li Fu, Aimin Yu, Lain-Jong LiCheng-Te Lin
Biosensors and Bioelectronics, 卷.99, 頁碼.85-91
01/2018

摘要

DNA hybridization Gold-transfer method Graphene biosensors Hall effect measurement Ultraclean surface Biotechnology Biophysics Biomedical Engineering Electrochemistry
The quality of graphene strongly affects the performance of graphene-based biosensors which are highly demanded for the sensitive and selective detection of biomolecules, such as DNA. This work reported a novel transfer process for preparing a residue-free graphene film using a thin gold supporting layer. A Hall effect device made of this gold-transferred graphene was demonstrated to significantly enhance the sensitivity (≈ 5 times) for hybridization detection, with a linear detection range of 1 pM to 100 nM for DNA target. Our findings provide an efficient method to boost the sensitivity of graphene-based biosensors for DNA recognition.

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