High yield and high specific activity synthesis of [<sup>18</sup>F] fallypride in a batch microfluidic reactor for micro-PET imaging

Muhammad Rashed Javed; Supin Chen; Jack Lei; Jeffrey Collins; Maxim Sergeev; Hee-Kwon Kim; Chang-Jin Kim; R. Michael Van Dam; Pei Yuin Keng

doi:10.1039/c3cc47616b

High yield and high specific activity synthesis of [<sup>18</sup>F] fallypride in a batch microfluidic reactor for micro-PET imaging

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High yield and high specific activity synthesis of [¹⁸F] fallypride in a batch microfluidic reactor for micro-PET imaging

Muhammad Rashed Javed, Supin Chen, Jack Lei, Jeffrey Collins, Maxim Sergeev, Hee-Kwon Kim, Chang-Jin Kim, R. Michael Van Dam 和 Pei Yuin Keng

Chemical Communications, 卷.50(10), 頁碼.1192-1194

02/2014

DOI: https://doi.org/10.1039/c3cc47616b

PMID: 24326303

摘要

Catalysis

Electronic

Optical and Magnetic Materials

Ceramics and Composites

Chemistry (all)

Surfaces

Coatings and Films

Metals and Alloys

Materials Chemistry

[¹⁸F]fallypride was synthesized in a batch microfluidic chip with a radiochemical yield of 65 ± 6% (n = 7) and an average specific activity of 730 GBq μmol^-1 (20 Ci μmol^-1) (n = 4). Specific activity was ∼2-fold higher than [¹⁸F]fallypride synthesized in a macroscale radiosynthesizer, despite starting with significantly less radioactivity, and thus safer conditions, in the microchip. © 2014 The Royal Society of Chemistry.

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題名: High yield and high specific activity synthesis of [¹⁸F] fallypride in a batch microfluidic reactor for micro-PET imaging
翻譯題名: High yield and high specific activity synthesis of [¹⁸F] fallypride in a batch microfluidic reactor for micro-PET imaging
創作者：: Muhammad Rashed Javed (作者) - University of California, Los Angeles
Supin Chen (作者) - University of California, Los Angeles
Jack Lei (作者) - University of California, Los Angeles
Jeffrey Collins (作者) - University of California, Los Angeles
Maxim Sergeev (作者) - University of California, Los Angeles
Hee-Kwon Kim (作者) - University of California, Los Angeles
Chang-Jin Kim (作者) - University of California, Los Angeles
R. Michael Van Dam (作者) - University of California, Los Angeles
Pei Yuin Keng (作者) - University of California, Los Angeles
學術資源類型: 期刊文章
出版日期: 02/2014
出版資訊: Chemical Communications, 卷.50(10), 頁碼.1192-1194
語言: 英語

High yield and high specific activity synthesis of [18F] fallypride in a batch microfluidic reactor for micro-PET imaging

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High yield and high specific activity synthesis of [¹⁸F] fallypride in a batch microfluidic reactor for micro-PET imaging