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Leucettamine B analogs and their carborane derivative as potential anti-cancer agents: Design, synthesis, and biological evaluation
期刊文章

Leucettamine B analogs and their carborane derivative as potential anti-cancer agents: Design, synthesis, and biological evaluation

M.-H. Hsu, C.-Y. Hsieh, M. Kapoor, J.-H. Chang, H.-L. Chu, T.-M. Cheng, K.-C. Hsu, T.E. Lin, F.-Y. Tsai 和 J.-C. Horng
Bioorganic Chemistry, 卷.98
2020
DOI: https://doi.org/10.1016/j.bioorg.2020.103729
Web of Science ID: WOS:000526784800030

摘要

Barbituric acid Carborane Leucettamine B Thiazolidinone Animals Antineoplastic Agents Boranes Cell Line, Tumor Cell Proliferation Cell Survival Chlorocebus aethiops Dose-Response Relationship, Drug Drug Design Drug Screening Assays, Antitumor Humans Imidazoles Molecular Structure Structure-Activity Relationship Vero Cells 5 (benzo[d] [1,3]diox ol 5 ylmethylene) 3 (1 carboranyl) 2 thioxothiazolidi n 4 one 5 (benzo[d] [1,3]diox ol 5 ylmethylene) 3 [2 (pyrrolidin 1yl)ethyl] 2 thioxothiazolidin 4 one 5 (benzo[d] [1,3]dioxol 5 ylmethylene) 1,3 bis(2 (pyrrolidin 1 yl)ethyl]imidazolidine 2,4 dione 5 (benzo[d] [1,3]dioxol 5 ylmethylene) 1,3 bis(2 morpholinoethyl) 2 thioxoimidazolidin 4 one 5 (benzo[d] [1,3]dioxol 5 ylmethylene) 1,3 bis(2 morpholinoethyl)imidazolidine 2,4 dione 5 (benzo[d] [1,3]dioxol 5 ylmethylene) 1,3 bis(3 morpholinopropyl) 2 thioxoimidazoli din 4 one 5 (benzo[d] [1,3]dioxol 5 ylmethylene) 1,3 bis(3 morpholinopropyl)imidazolidine 2,4 dione 5 (benzo[d] [1,3]dioxol 5 ylmethylene) 1,3 bis[2 (piperidin 1 yl) 2 thioxoimidazo lidin 4 one 5 (benzo[d] [1,3]dioxol 5 ylmethylene) 1,3 bis[2 (piperidin 1 yl)ethyl]imidazolidine 2 4 dione 5 (benzo[d] [1,3]dioxol 5 ylmethylene) 1,3 bis[2 (pyrrolidin 1 yl)ethyl] 2 thioxoimidaz olidin 4 one 5 (benzo[d] [1,3]dioxol 5 ylmethylene) 1,3 dimethylpyrimidine 2,4,6(1h,3h,5h)trione 5 (benzo[d] [1,3]dioxol 5 ylmethylene) 2 thioxodihydropyrimidine 4,6(1h,5h)dione 5 (benzo[d] [1,3]dioxol 5 ylmethylene) 2 thioxoimidazolidin 4 one 5 (benzo[d] [1,3]dioxol 5 ylmethylene) 2 thioxothiazolidin 4 one 5 (benzo[d] [1,3]dioxol 5 ylmethylene) 3 (1 carboranyl) 2 thioxothiazolidi n 4 one 5 (benzo[d] [1,3]dioxol 5 ylmethylene) 3 (2 morpholinoethyl) 2 thioxothiazolidin 4 one 5 (benzo[d] [1,3]dioxol 5 ylmethylene) 3 (3 morpholinopropyl) 2 thioxothiazolidin 4 one 5 (benzo[d] [1,3]dioxol 5 ylmethylene) 3 (3 morpholinopropyl)thiazolidine 2,4 dione 5 (benzo[d] [1,3]dioxol 5 ylmethylene) 3 (prop 2 yn 1 yl)thiazolidine 2 4 dione 5 (benzo[d] [1,3]dioxol 5 ylmethylene) 3 [2 (piperidin 1 yl)ethyl] 2 thiazolidine 2 4 dione 5 (benzo[d] [1,3]dioxol 5 ylmethylene) 3 [2 (piperidin 1 yl)ethyl] 2 thioxothiazolidin 4 one 5 (benzo[d] [1,3]dioxol 5 ylmethylene) 3 [2 (pyrrolidin 1 yl)ethyl]thiazolidine 2 4 dione 5 (benzo[d] [1,3]dioxol 5 ylmethylene) 3 [2 (pyrrolidin 1yl)ethyl] 2 thioxothiazolidin 4 one 5 (benzo[d] [1,3]dioxol 5 ylmethylene)imidazolidine 2,4 dione 5 (benzo[d] [1,3]dioxol 5 ylmethylene)thiazolidine 2,4 dione 5 (benzo[d][1,3]dioxol 5 ylmethylene)pyrimidine antineoplastic agent carborane derivative leucettamine b derivative unclassified drug antineoplastic agent borane derivative imidazole derivative leucettamine B antineoplastic activity Article boron nuclear magnetic resonance cancer chemotherapy cell viability controlled study drug design drug screening drug synthesis human human cell Knoevenagel condensation Mahlavu cell line MDA-MB-468 cell line microwave radiation nuclear magnetic resonance priority journal proton nuclear magnetic resonance structure activity relation SW480 cell line thin layer chromatography X ray diffraction animal cell proliferation cell survival chemical structure chemistry Chlorocebus aethiops dose response drug effect drug screening synthesis tumor cell line Vero cell line

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