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Multi-enzyme one-pot strategy for the synthesis of sialyl Lewis X-containing PSGL-1 glycopeptide
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Multi-enzyme one-pot strategy for the synthesis of sialyl Lewis X-containing PSGL-1 glycopeptide

Kuo-Ting Huang, Bing-Ching Wu, Chang-Ching Lin, Shih-Chi Luo, Chinpan Chen, Chi-Huey Wong 和 Chun-Cheng Lin
Carbohydrate Research, 卷.341(12), 頁碼.2151-2155
09/2006
DOI: https://doi.org/10.1016/j.carres.2006.04.047
PMID: 16762328

摘要

Glycopeptide Glycosyltransferase One-pot synthesis PSGL-1 Sialyl Lewis X Analytical Chemistry Biochemistry Organic Chemistry
An enzymatic one-pot three-step glycosylation strategy was developed for the synthesis of sLe x moiety of truncated PSGL-1 glycopeptide with and without sulfation. The method provided an efficient way to afford complex glycopeptides in a semi-preparative scale without further complicated and time-consuming purification process in each glycosylation step. © 2006 Elsevier Ltd. All rights reserved.

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