摘要
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•Polyherbal biocompatible natural polymer gel is prepared for wound healing study.•Polyherbal gel is biocompatible, non-toxic and improved the cell viability.•The polyherbal gel accelerates wound contraction and reduces re-epithelialization.
Polyherbal biocompatible natural polymer gel was prepared to study the wound healing properties in skin tissue engineering. The natural biopolymer-based polyherbal gel mimicked the extracellular matrix (ECM) properties and had a strong antioxidant and anti-inflammatory properties. In vitro cell viability was examined using male foreskin fibroblasts (HS68) and the results revealed that the polyherbal compound gel was biocompatible and nontoxic and could improve the cell viability significantly. In vivo wound healing results showed faster, significant wound contraction (p < 0.001), and reduced re-epithelialization (p < 0.001) in polyherbal gel treatment compared to the control. Hence, the polyherbal gel developed in this study could be a promising material for wound healing applications.