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New detritylation method for nucleosides and nucleotides by ceric ammonium nitrate
Journal article   Peer reviewed

New detritylation method for nucleosides and nucleotides by ceric ammonium nitrate

Jih Ru Hwu, Moti L. Jain, Shwu-Chen Tsay and Gholam H. Hakimelahi
Chemical Communications, (4), pp.545-546
1996

Abstract

The trityl and monomethoxytrityl groups are efficiently (80-98% yields) removed from protected nucleosides or nucleotides by use of 0.10 equivalent of Ce(NH 4 ) 2 (NO 3 ) 6 in wet acetonitrile and DMF under neutral conditions.

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