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Optimizing electron-capture detector performance for gas chromatographic analysis of polychlorinated biphenyls
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Optimizing electron-capture detector performance for gas chromatographic analysis of polychlorinated biphenyls

C.-Y. ChenY.-C. Ling
Chromatographia, 卷.33(5-6), 頁碼.272-278
03/1992

摘要

Electron-capture detector Gas chromatography Polychlorinated biphenyls Principal component factor analysis Simplex optimization Analytical Chemistry Biochemistry Clinical Biochemistry Organic Chemistry
A modified simplex technique has been applied to optimize the performance of an electron-capture detector under constant-current and constant-frequency pulse modes for the gas chromatographic analysis of polychlorinated biphenyls. Optimal performance was obtained by adjusting the four experimental parameters of pulse voltage, detector temperature, make-up gas flow rate, and reference current (or pulse frequency) using the signal-to-noise ratio of the eluting peak as the criterion. The results show that constant-current pulse mode has better sensitivity and dynamic range whereas the constant-frequency pulse mode has the lower detection limit. Subsequent principal component factor analysis indicated that similar performance is achievable using only three parameters. © 1992 Friedr. Vieweg & Sohn Verlagsgesellschaft mbH.

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