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Paper - a potential platform in pharmaceutical development
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Paper - a potential platform in pharmaceutical development

Yi-Hsun Chen, Zong-Keng KuoChao-Min Cheng
Trends in Biotechnology, 卷.33(1), 頁碼.1-9
01/2015

摘要

Bioassay Clinically based diagnostics in hospital Diagnostics Paper-based microfluidic device Point-of-care diagnostics Translational medicine Biotechnology Bioengineering
Paper is predominantly composed of cellulose fibers that have an inherent ability to wick fluids by capillary action; it provides an interesting diagnostic platform that is inexpensive, easily obtained, and eco-friendly. Paper has been used in various types of biologically relevant applications including paper-based molecular assays, paper-based ELISA (P-ELISA), paper-based nucleic acid assays, and paper-based cell assays. Based on recent successes with the use of paper as a platform, we contend that paper is not only very suitable for diagnostics but could provide a more advantageous platform than current plastics-based platforms for drug discovery, and would be useful for accomplishing in vitro pre-compound screening steps while offering a possible solution to several economic obstacles inherent in the pharmaceutical industry.

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