摘要
Fluorescence spectra of a pyrene-substituted poly (acrylic acid) (1) were measured in the presence of dipalmitoylphosphatidylglycerol (DPPG) at pH values of 4 and 7 to investigate the interactions between 1 and phospholipids. These photophysical investigations showed that at pH 4 mixed micelles of 1 and phospholipids were formed with the incorporation of 1 in the hydrophobic core of the mixed micelle. The measurements of fluorescence decay and quenching of fluorescence by nitromethane in solutions of 1 and DPPG also supported this model for the interactions of 1 and phospholipids. These results were in agreement with a calorimetric investigation of the interactions between phospholipids and poly(acrylic acid) derivatives (Tirrell, D. A.; Takigawa, D. Y.; Seki, K. Ann. N.Y. Acad. Sci. 1985, 446, 237). The effects of head group and temperature on the interactions of 1 and phospholipids were also investigated. © 1986, American Chemical Society. All rights reserved.