Abstract
A model of competition for two complementary nutrients between plasmid-bearing and plasmid-free organisms in a chemostat is proposed. A rigorous mathematical analysis of the global asymptotic behavior of the model is presented. The work extends the model of competition for a single-limited nutrient studied by Stephanopoulos and Lapidus [Chem. Engng. Sci. 443 (1988) 49] and Hsu, Waltman and Wolkowicz [J. Math. Biol. 32 (1994) 731]. © 2002 Published by Elsevier Science Inc.