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Preparation and characterization of thermal-sensitive ferrofluids for drug delivery application
Journal article   Peer reviewed

Preparation and characterization of thermal-sensitive ferrofluids for drug delivery application

Ting-Yu Liu, Shang-Hsiu Hu, Sheng-Hsiang Hu, Szu-Ping Tsai and San-Yuan Chen
Journal of Magnetism and Magnetic Materials, Vol.310(2 SUPPL. PART 3), pp.2850-2852
03/2007

Abstract

Core-shell Drug delivery Ferrofluid Magnetic nanoparticle Pluronic F127 Thermal sensitive
Novel thermal-sensitive ferrofluids (F127-ferrofluids) consisting of core-shell-type magnetic nanoparticles dispersed in Pluronic F127-containing aqueous solution were prepared. The core (magnet)-shell (Pluronic F127) nanoparticles were synthesized by in situ co-precipitation process, which were characterized using transmission electron microscope, X-ray diffraction and vibrating sample magnetometer. The F127-ferrofluids gelled above the lower critical solution temperatures (LCST) of approximately 23-28 °C, which were higher than that of pure Pluronic F127-fluids (21-25 °C). The increase in the LCST of the F127 ferrofluids may be attributed to a result of a physical interaction between the F127 molecules and the core-shell magnetic nanoparticles. © 2006 Elsevier B.V. All rights reserved.

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