Pulsatile drug release from PLGA hollow microspheres by controlling the permeability of their walls with a magnetic field

Wei-Lun Chiang; Cherng-Jyh Ke; Zi-Xian Liao; San-Yuan Chen; Chun-Ying Tsai; Younan Xia; Hsing-Wen Sung

doi:10.1002/smll.201201743

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Pulsatile drug release from PLGA hollow microspheres by controlling the permeability of their walls with a magnetic field

Journal article

Peer reviewed

Pulsatile drug release from PLGA hollow microspheres by controlling the permeability of their walls with a magnetic field

Wei-Lun Chiang, Cherng-Jyh Ke, Zi-Xian Liao, San-Yuan Chen, Chun-Ying Tsai, Younan Xia and Hsing-Wen Sung

Small, Vol.8(23), pp.3584-3588

07/12/2012

DOI: https://doi.org/10.1002/smll.201201743

Abstract

iron oxide nanoparticles

magnetic stimulus

molecular switches

pulsatile drug release

Pulsatile release: When a high-frequency magnetic field is applied, heat will be generated by coupling to the iron oxide nanoparticles encapsulated in the shells of PLGA hollow microspheres. As the temperature approaches the T _g of PLGA, the polymer chains become more mobile, subsequently increasing the free volume of PLGA matrix and significantly enhancing the diffusion of drug molecules. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Title: Pulsatile drug release from PLGA hollow microspheres by controlling the permeability of their walls with a magnetic field
Creators - without role: Wei-Lun Chiang - Department of Chemical Engineering , National Tsing Hua University
Cherng-Jyh Ke - Department of Chemical Engineering , National Tsing Hua University
Zi-Xian Liao - Department of Chemical Engineering , National Tsing Hua University
San-Yuan Chen - Department of Materials Science and Engineering , National Chiao-Tung University
Chun-Ying Tsai - Department of Chemical Engineering , National Tsing Hua University
Younan Xia - Georgia Institute of Technology
Hsing-Wen Sung - Department of Chemical Engineering , National Tsing Hua University
Publication Details: Small, Vol.8(23), pp.3584-3588
Identifiers: 9957770455406774
Academic Unit: Institute of Biomedical Engineering, College of Engineering, National Tsing Hua University
Language: English
Resource Type: Journal article

Pulsatile drug release from PLGA hollow microspheres by controlling the permeability of their walls with a magnetic field

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