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Rapidly reversible manipulation of molecular activity with dual chemical dimerizers
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Rapidly reversible manipulation of molecular activity with dual chemical dimerizers

Yu-Chun Lin, Yuta Nihongaki, Tzu-Yu Liu, Shiva Razavi, Moritoshi Sato 和 Takanari Inoue
Angewandte Chemie - International Edition, 卷.52(25), 頁碼.6450-6454
06/2013
DOI: https://doi.org/10.1002/anie.201301219
PMID: 23649661

摘要

cell signaling chemically inducible dimerization enzymes phosopholipids reversible perturbation Chemistry (all) Catalysis
Tell it where to go: Rapamycin induced the relocation of an FRB-fused protein of interest (POI) to the plasma membrane (labeled with the fusion protein GAIs-FKBP-C2(LACT)) to activate a signaling event (see picture). Subsequent treatment with a gibberellic acid ester led to the relocation of the whole GAIs-FKBP-C2(LACT)/rapamycin/FRB-POI complex to the Tom20-GID1-labeled mitochondria with the termination of POI-dependent signaling. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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