Logo image
Reactivity of [K3(phen)8][Cu(NPh2) 2]3 - A possible intermediate in the copper(i)-catalyzed N-arylation of N-phenylaniline
Journal article   Peer reviewed

Reactivity of [K3(phen)8][Cu(NPh2) 2]3 - A possible intermediate in the copper(i)-catalyzed N-arylation of N-phenylaniline

Chia-Kai Tseng, Chi-Rung Lee, Mei-Chun Tseng, Chien-Chung Han and Shin-Guang Shyu
Dalton Transactions, Vol.43(19), pp.7020-7027
21/05/2014

Abstract

Complex [K 3 (phen) 8 ][Cu(NPh 2 ) 2 ] 3 (1, phen = phenanthroline) was isolated from the catalytic C-N cross coupling reaction based on the CuI-phen-tBuOK catalytic system. Complex 1 can react with 4-iodotoluene to give 4-methyl-N,N- diphenylaniline (3a) in 50% yield (based on all available NPh 2 - ligands of complex 1). In addition, 1 can also work as an effective catalyst for the C-N coupling reactions under the same reaction conditions, indicating that 1 may be an effective intermediate of the catalytic system. In the presence of 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO), a radical scavenger, the stoichiometric reaction between complex 1 and 4-iodotoluene was significantly quenched to give a low yield of 12%. The results suggest that the radical path dominates in the reaction, with (phen)KNPh 2 as the possible radical source. The structures of 1 and (phen)KNPh 2 were both determined by single crystal X-ray diffraction studies. © 2014 the Partner Organisations.

Metrics

1 Record Views

Details

Logo image