Regiocontrolled gold-catalyzed [2+2+2] cycloadditions of ynamides with two discrete nitriles to construct 4-aminopyrimidine cores

Somnath Narayan Karad; Rai-Shung Liu

doi:10.1002/anie.201405312

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Regiocontrolled gold-catalyzed [2+2+2] cycloadditions of ynamides with two discrete nitriles to construct 4-aminopyrimidine cores

Journal article

Peer reviewed

Regiocontrolled gold-catalyzed [2+2+2] cycloadditions of ynamides with two discrete nitriles to construct 4-aminopyrimidine cores

Somnath Narayan Karad and Rai-Shung Liu

Angewandte Chemie - International Edition, Vol.53(34), pp.9072-9076

18/08/2014

DOI: https://doi.org/10.1002/anie.201405312

Abstract

cycloadditions

gold

heterocycles

homogeneous catalysis

synthetic methods

Reported herein is the novel gold-catalyzed intermolecular [2+2+2] cycloaddition of ynamides with two discrete nitriles to form monomeric 4-aminopyrimidines, which are pharmaceutically important structural motifs. The utility of this new cycloaddition is demonstrated by the excellent regioselectivity obtained using a variety of ynamides and nitriles. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Title: Regiocontrolled gold-catalyzed [2+2+2] cycloadditions of ynamides with two discrete nitriles to construct 4-aminopyrimidine cores
Creators - without role: Somnath Narayan Karad - National Tsing Hua University
Rai-Shung Liu - Department of Chemistry, National Tsing Hua University
Publication Details: Angewandte Chemie - International Edition, Vol.53(34), pp.9072-9076
Identifiers: 9957769622206774
Academic Unit: Department of Chemistry, College of Science, National Tsing Hua University
Language: English
Resource Type: Journal article

Regiocontrolled gold-catalyzed [2+2+2] cycloadditions of ynamides with two discrete nitriles to construct 4-aminopyrimidine cores

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