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Rhodium(III)-catalyzed in situ oxidizing directing group- assisted C-H bond activation and olefination: A route to 2-vinylanilines
Journal article   Peer reviewed

Rhodium(III)-catalyzed in situ oxidizing directing group- assisted C-H bond activation and olefination: A route to 2-vinylanilines

Krishnamoorthy Muralirajan, Radhakrishnan Haridharan, Sekar Prakash and Chien-Hong Cheng
Advanced Synthesis and Catalysis
2015

Abstract

2-vinylanilines Alkenes C-H activation In situ oxidizing directing group Rhodium
A new and efficient method for the synthesis of 2-vinylanilines from the reaction of arylhydrazine hydrochlorides with alkenes and diethyl ketone via a rhodium-catalyzed C-H activation is described. The oxidant-free olefination reaction involves the in situ generation of an -N-NCR 1 R 2 moiety as the oxidizing directing group thus providing an easy access to 2-vinylanilines.

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