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Selective synthesis of chiral dioxabicyclo[4.4.0]decane and Dioxabicyclo[5.3.0]decane from 3,4-Bisallyloxy-but-1-yne derivatives via ruthenium-catalyzed en-yn-ene metathesis
Journal article   Peer reviewed

Selective synthesis of chiral dioxabicyclo[4.4.0]decane and Dioxabicyclo[5.3.0]decane from 3,4-Bisallyloxy-but-1-yne derivatives via ruthenium-catalyzed en-yn-ene metathesis

Chang-Jung Wu, Reniguntala J. Madhushaw and Rai-Shung Liu
Journal of Organic Chemistry, Vol.68(20), pp.7889-7892
03/10/2003

Abstract

We prepared a series of chiral 3,4-bisallyloxybut-1-ynes having syn and anti configurations. Treatment of these substrates with Grubbs catalyst Cl <sub>2</sub> (PCy <sub>3</sub> ) <sub>2</sub> Ru = CHPh (3 mol %) preferably gave chiral dioxabicyclo[4.4.0]-decane (yields > 55%) in addition to dioxabicyclo[5.3.0]-decane in minor proportions. On substitution of the 4-allyloxy group of these substrates with a 4-but-2-enyloxy group, the metathesis reactions produced only dioxabicyclo [5.3.0] decane in the presence of Grubbs ruthenium-imidazolidene carbene catalyst.

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